Institute of Physics of Materials AS CR, v. v. i. > Projects > Multicentric evaluation of hypersensitivity reactions in patients indicated for total joint replacement including evaluation of the reasons for reimplanting

Multicentric evaluation of hypersensitivity reactions in patients indicated for total joint replacement including evaluation of the reasons for reimplanting

Co-investigatorprof. RNDr. Antonín Dlouhý, CSc.
Number of ProjectNU20-08-00149
Internal Project Number420210
AgencyMinisterstvo zdravotnictví České republiky
Duration2020-05-01 - 2023-12-31

Anotace
Total-joint arthroplasty is one of the most successful and effective orthopedic operations performed during the last century. In the present project, we intend to monitor and compare heavy metal load in circulation, especially Ti, Co, Cr, Ni, in patients after implantation of joint replacement compared to the Czech Republic without implants of any metal. The correlation of the healing process dynamics and the tolerance of the metal material will be evaluated with clinical symptomatology, functional parameters with respect to the development and course of complications after implantation of the endoprostheses, including reimplantation. Processes associated with the activation of the immune system, including hypersensitivity reactions, will be simulated on an in vitro model using individual patient immune systems. Attempting to find predictive markers associated with poor prognosis after implantation in peripheral blood could lead to early detection of complications. The metal surface of the explanted substitutes will be evaluated in terms of wear, corrosion, metal defects.


2024

Luptáková N., Dlouhý V., Sobola D., Fintová S., Weiser A., Beneš 3rd V., Dlouhý A.: Interfaces between cranial bone and AISI 304 steel after long-term implantation: A case study of cranial screws. ACS Biomaterials Science & Engineering 10 (2024) 4297-4310



2023

Šromová V., Sobola D., Kaspar P.: A brief review of bone cell function and importance. Cells 12 (2023) 2576